Allele Frequency Calculator
Calculate allele frequencies and carrier probability using Hardy-Weinberg equilibrium equation
Calculate Allele Frequency
Frequency of people with the disease as percentage
Hardy-Weinberg Results
Allele Frequencies
Genotype Frequencies
Hardy-Weinberg equation: p² + 2pq + q² = 1
Disease frequency (q²): Not calculated
Total verification: 0.0000% = 100%
Genetic Risk Assessment
Common Recessive Genetic Diseases
| Disease | Population | Frequency | q (approx) |
|---|---|---|---|
| Cystic Fibrosis | Caucasian | 1 in 2,500 | 0.020 |
| Sickle Cell Anemia | African-American | 1 in 600 | 0.041 |
| Tay-Sachs | Ashkenazi Jewish | 1 in 3,600 | 0.017 |
| Phenylketonuria | Caucasian | 1 in 15,000 | 0.008 |
| Albinism | General | 1 in 10,000 | 0.010 |
Example Calculation
Cystic Fibrosis in Caucasian Population
Disease frequency: 1 in 2,500 people (0.0004 or 0.04%)
Given: q² = 0.0004
Calculate q: q = √0.0004 = 0.02
Calculate p: p = 1 - 0.02 = 0.98
Results
Healthy homozygotes (p²): 0.98² = 96.04%
Carriers (2pq): 2 × 0.98 × 0.02 = 3.92%
Affected (q²): 0.02² = 0.04%
Carrier frequency: 1 in 25 people (approximately)
Hardy-Weinberg Conditions
No mutations occurring
Random mating
No gene flow (migration)
Large population size
No natural selection
Key Definitions
Allele
Variant form of a gene
Carrier
Person with one mutant allele (Aa)
Homozygous
Two identical alleles (AA or aa)
Heterozygous
Two different alleles (Aa)
Gene Pool
Total genetic diversity in a population
Understanding Allele Frequency and Hardy-Weinberg Equilibrium
What is Allele Frequency?
Allele frequency describes how often a particular allele appears in a population. It's crucial for understanding genetic diversity, disease prevalence, and inheritance patterns in populations.
Clinical Applications
- •Genetic counseling for family planning
- •Population screening programs
- •Risk assessment for recessive diseases
- •Evolutionary biology studies
Hardy-Weinberg Equation
p² + 2pq + q² = 1
p + q = 1
- p: Frequency of dominant/healthy allele
- q: Frequency of recessive/mutant allele
- p²: Frequency of healthy homozygotes (AA)
- 2pq: Frequency of carriers (Aa)
- q²: Frequency of affected individuals (aa)
Remember: This equation assumes random mating and no evolutionary forces acting on the population.