Reconstitution Calculator
Calculate reconstitution concentration for medications and solutions using dry ingredients and diluents
Calculate Reconstitution Parameters
Amount of medication or dry ingredient to reconstitute
Volume of diluent (water, saline, etc.) to add
Reconstitution Formulas
Concentration: C = Dose ÷ Volume
Required Volume: V = Dose ÷ Concentration
Required Dose: D = Concentration × Volume
Units: Concentration typically expressed as mg/ml or μg/ml
Example Calculation
Vancomycin Reconstitution Example
Medication: Vancomycin vial containing 500 mg powder
Instructions: Add 10 ml of sterile water for injection
Goal: Calculate the final concentration
Step-by-Step Solution
1. Identify the dose: 500 mg
2. Identify the diluent volume: 10 ml
3. Apply the formula: Concentration = 500 mg ÷ 10 ml
4. Calculate result: Concentration = 50 mg/ml
Result: Final concentration = 50 mg/ml
Common Medications
Vancomycin
500 mg + 10 ml = 50 mg/ml
Ceftriaxone
1000 mg + 10 ml = 100 mg/ml
Ampicillin
250 mg + 5 ml = 50 mg/ml
Penicillin G
1000000 units + 20 ml = 50000 mg/ml
Cefazolin
500 mg + 2 ml = 250 mg/ml
Gentamicin
80 mg + 2 ml = 40 mg/ml
Tobramycin
80 mg + 2 ml = 40 mg/ml
Amikacin
500 mg + 2 ml = 250 mg/ml
Safety Guidelines
Always check medication labels carefully
Use sterile diluents only
Follow manufacturer instructions
Check expiration dates before and after reconstitution
Store reconstituted solutions properly
This calculator is for educational purposes only
Understanding Reconstitution
What is Reconstitution?
Reconstitution is the process of adding a liquid (diluent) to a dry ingredient to obtain a specific concentration of the resultant solution. This is commonly used in pharmacy to prepare injectable medications from powdered forms.
Common Applications
- •Injectable antibiotics (penicillin, cephalosporins)
- •Chemotherapy drugs
- •Vaccines and immunoglobulins
- •Nutritional supplements
- •Laboratory reagents
Key Formula
Concentration = Dose ÷ Volume
C (mg/ml) = D (mg) ÷ V (ml)
Important Considerations
- Sterility: Use only sterile diluents
- Compatibility: Check drug-diluent compatibility
- Stability: Note storage requirements after reconstitution
- Accuracy: Measure volumes and doses precisely
- Labeling: Label reconstituted solutions clearly
Disclaimer: This calculator is for educational purposes only. Always consult healthcare professionals for medication preparation.