Carboplatin Calculator
Calculate carboplatin chemotherapy dose using the Calvert formula and patient parameters
Calculate Carboplatin Dose
Oncology Professional Use Only
This calculator is for qualified oncology professionals only. Carboplatin is a cytotoxic chemotherapy agent requiring specialized training, monitoring, and institutional protocols. Never use without proper medical supervision and protocol verification.
Adult patients 18+ years
Affects GFR calculation (x0.85 for female)
Consider adjusted weight for obese patients
Prevents GFR overestimation in low creatinine patients
Standard dosing for most solid tumors
Carboplatin Dosing Results
Enter patient parameters to calculate carboplatin dose
Clinical Considerations
- • Verify dose with institutional carboplatin protocols
- • Consider 24-hour urine collection for AUC > 6 or GFR > 125
- • Monitor CBC, platelets, and renal function
- • Adjust for body surface area per institutional policy
- • Consider dose reduction for prior nephrotoxic therapy
Example Calculation
50-year-old Male Patient
Patient: 50-year-old male, 78 kg
Serum creatinine: 1.2 mg/dL
Target AUC: 7 mg/ml/min
GFR calculation:
• GFR = ((140 - 50) x 78) / (72 x 1.2)
• GFR = (90 x 78) / (72 x 1.2) = 7020 / 86.4 = 81.25 ml/min
Carboplatin dose:
• Dose = 7 x (81.25 + 25) = 7 x 106.25 = 743.8 mg
AUC Guidelines
Standard dosing for most solid tumors
Higher dosing for combination regimens
High-dose protocols, requires monitoring
Renal Function
Normal: ≥90 ml/min
Standard dosing
Mild: 60-89 ml/min
Monitor closely
Moderate: 30-59 ml/min
Consider dose adjustment
Severe: <30 ml/min
Nephrology consultation
Understanding Carboplatin Dosing
What is Carboplatin?
Carboplatin is a platinum-based chemotherapy medication used to treat various cancers including ovarian, lung, and brain cancers. Unlike many chemotherapy drugs, carboplatin dosing is based on kidney function rather than body surface area because 70% is eliminated unchanged by the kidneys.
Why Use the Calvert Formula?
- •Accounts for individual kidney function (GFR)
- •Targets specific drug exposure (AUC)
- •Reduces toxicity compared to BSA-based dosing
- •Standardized approach across institutions
Formula Components
Carboplatin Dose = AUC x (GFR + 25)
- AUC: Target area under curve (mg/ml/min)
- GFR: Glomerular filtration rate (ml/min)
- 25: Constant for non-renal clearance
Maximum Dose Consideration: For patients with excellent renal function (GFR > 125), consider capping GFR at 125 ml/min to prevent excessive dosing.