Fresh Frozen Plasma Dose Calculator
Calculate FFP dosing for coagulation factor replacement and bleeding management
Calculate FFP Dose
Patient body weight for dose calculation
Volume per FFP unit (typically 200-250 mL)
Therapeutic range: 10-20 mL/kg (increases coagulation factors by 20-30%)
FFP Dosing Results
Dosing Assessment
Standard therapeutic dose - appropriate for most indications
⚠️ Critical Medical Disclaimer: This calculator provides dosing estimates only. FFP administration requires proper blood typing, crossmatching, and clinical assessment. Always verify compatibility, follow institutional protocols, and monitor for transfusion reactions. Never administer FFP for volume expansion. These calculations are for educational purposes and must be validated by qualified medical professionals.
Clinical Guidelines
• Standard dose: 10-15 mL/kg for most indications
• Severe bleeding: 15-20 mL/kg may be required
• Infusion rate: One unit over 30 minutes, complete within 4 hours
• Monitoring: Vital signs, transfusion reactions, coagulation studies
• Compatibility: ABO compatible, Rh matching not required
Example Clinical Scenario
Patient Case
Patient: 70 kg adult with severe bleeding
Indication: Coagulation factor replacement
INR: 2.5 (elevated)
Dose recommendation: 15 mL/kg (standard)
Available FFP units: 250 mL each
Calculation
Total dose needed: 70 kg × 15 mL/kg = 1,050 mL
Units required: 1,050 mL ÷ 250 mL/unit = 4.2 → 5 units
Actual volume: 5 units × 250 mL = 1,250 mL
Actual dose: 1,250 mL ÷ 70 kg = 17.9 mL/kg
Administration time: ~150 minutes (30 min/unit)
FFP Indications
Severe Bleeding
Active hemorrhage with coagulopathy
Coagulation Defects
Factor deficiency, liver disease
Warfarin Reversal
Emergency anticoagulation reversal
DIC/TTP
Specialized coagulation disorders
Administration
Thaw at 37°C for 30 minutes
ABO compatible plasma required
30 minutes per unit infusion
Monitor for transfusion reactions
Do NOT use for volume expansion
Understanding Fresh Frozen Plasma (FFP)
What is FFP?
Fresh Frozen Plasma (FFP) is the liquid portion of blood that contains all coagulation factors, proteins, and clotting elements. It's obtained from whole blood donations and frozen within 8 hours to preserve the activity of labile coagulation factors.
Composition
- •All coagulation factors (I-XIII)
- •Albumin and immunoglobulins
- •Antithrombin III and protein C/S
- •von Willebrand factor
Dosing Principles
FFP dosing is weight-based and depends on the clinical indication. The goal is to achieve hemostatic levels of coagulation factors (typically >30% of normal activity).
Dose (mL) = Weight (kg) × mL/kg dose
Units needed = Total dose ÷ Unit volume
Expected Outcomes
- 10-15 mL/kg: 20-30% increase in factor levels
- 15-20 mL/kg: 30-40% increase in factor levels
- Clinical effect: Improved hemostasis, normalized PT/PTT
Safety Considerations
Contraindications
- • Volume overload risk
- • IgA deficiency with anti-IgA antibodies
- • Isolated factor deficiency (use specific factors)
- • Chronic coagulopathy (unless acute bleeding)
Complications
- • Transfusion reactions (allergic, febrile)
- • TRALI (transfusion-related acute lung injury)
- • Volume overload
- • Infectious disease transmission (rare)