NAFLD Fibrosis Score Calculator
Assess liver fibrosis risk in patients with non-alcoholic fatty liver disease (NAFLD)
Calculate NAFLD Fibrosis Score
Personal Details
Age in years
Height in cm
Weight in kg
Impaired fasting glucose or diabetes mellitus
Laboratory Test Results
Aspartate aminotransferase (IU/L)
Alanine aminotransferase (IU/L)
Platelet count (× 10⁹/L)
Serum albumin level
NAFLD Fibrosis Score Results
Enter all required values to calculate the NAFLD Fibrosis Score
Example Calculation
Patient Example
Age: 55 years
BMI: 28.5 kg/m²
Hyperglycemia: Yes (diabetes)
AST: 45 IU/L
ALT: 38 IU/L
AST/ALT Ratio: 1.18
Platelet Count: 210 × 10⁹/L
Albumin: 3.8 g/dL
Calculation
NFS = -1.675 + (0.037 × 55) + (0.094 × 28.5) + (1.13 × 1) + (0.99 × 1.18) - (0.013 × 210) - (0.66 × 3.8)
NFS = -1.675 + 2.035 + 2.679 + 1.13 + 1.168 - 2.73 - 2.508
NFS = -0.099
Interpretation: Intermediate score (further evaluation needed)
About NAFLD
Non-alcoholic fatty liver disease (NAFLD) affects approximately 25% of the global population and is one of the most common causes of chronic liver disease.
Risk Factors:
- • Obesity and overweight
- • Type 2 diabetes
- • Metabolic syndrome
- • High fructose diet
- • Advancing age
Score Interpretation
< -1.455
Low probability of advanced fibrosis
-1.455 to 0.676
Intermediate score - further evaluation needed
> 0.676
High probability of advanced fibrosis
Clinical Use
Non-invasive assessment of liver fibrosis
Helps avoid unnecessary liver biopsy
Validated in multiple patient populations
Useful for monitoring disease progression
Understanding NAFLD Fibrosis Score
What is NAFLD?
Non-alcoholic fatty liver disease (NAFLD) is a condition characterized by excessive fat accumulation in the liver without significant alcohol consumption. It can progress from simple steatosis to non-alcoholic steatohepatitis (NASH) and eventually to cirrhosis.
Why Use the NAFLD Fibrosis Score?
- •Non-invasive alternative to liver biopsy
- •High accuracy in excluding advanced fibrosis
- •Uses readily available laboratory parameters
- •Validated across diverse patient populations
Score Components
Clinical Parameters:
- • Age (years)
- • BMI (kg/m²)
- • Presence of hyperglycemia/diabetes
Laboratory Parameters:
- • AST/ALT ratio
- • Platelet count (× 10⁹/L)
- • Albumin level (g/dL)
Important: This score should be interpreted in conjunction with clinical assessment and other diagnostic tests. Always consult with a hepatologist for comprehensive evaluation.