PSA Density Calculator
Calculate PSA density to help differentiate between prostate cancer and benign prostatic hyperplasia
Calculate PSA Density
Prostate-specific antigen level from blood test
From mpMRI or transrectal ultrasound (TRUS)
PSA Density Results
Formula: PSA Density = PSA Level (ng/mL) / Prostate Volume (mL)
Threshold: ≥0.15 ng/mL² suggests suspicion of prostate cancer
⚠️ Medical Disclaimer: This calculator is for educational purposes only and should not replace professional medical advice. Always consult with a qualified healthcare provider for proper diagnosis and treatment decisions.
PSA Density Interpretation
< 0.10 ng/mL²: Generally considered low risk for prostate cancer
0.10-0.14 ng/mL²: Intermediate risk, requires clinical correlation
≥ 0.15 ng/mL²: Elevated risk, consider biopsy evaluation
Example Calculation
Clinical Scenario
Patient: 65-year-old male with elevated PSA
PSA Level: 6.8 ng/mL
Prostate Volume (TRUS): 45.2 mL
Calculation
PSA Density = PSA Level / Prostate Volume
PSA Density = 6.8 ng/mL ÷ 45.2 mL
PSA Density = 0.150 ng/mL²
Result: At threshold value - warrants urological consultation
About PSA
What is PSA?
Prostate-Specific Antigen (PSA) is a protein produced by prostate cells. Elevated levels may indicate prostate cancer, BPH, or prostatitis.
Normal PSA Levels
- • Ages 40-49: < 2.5 ng/mL
- • Ages 50-59: < 3.5 ng/mL
- • Ages 60-69: < 4.5 ng/mL
- • Ages 70+: < 6.5 ng/mL
Prostate Cancer Risk Factors
Age (>50 years)
Family history
African American ethnicity
Genetic mutations (BRCA1/2)
Clinical Tips
PSA density helps differentiate cancer from BPH in mildly elevated PSA cases
Consider age, family history, and digital rectal exam findings
Low PSA density doesn't completely exclude prostate cancer
Understanding PSA Density
What is PSA Density?
PSA density is a calculation that divides the PSA level by the prostate volume. It helps distinguish between prostate cancer and benign prostatic hyperplasia (BPH) in patients with mildly elevated PSA levels.
Clinical Significance
- •Helps determine need for prostate biopsy
- •Improves specificity of PSA testing
- •Reduces unnecessary biopsies in BPH cases
- •Assists in risk stratification
Measurement Methods
Multiparametric MRI (mpMRI)
Most accurate method for prostate volume measurement. Provides detailed imaging of prostate anatomy and can detect suspicious lesions.
Transrectal Ultrasound (TRUS)
Commonly used method that measures prostate dimensions. Uses formula: Volume = (L × W × H × π) / 6
Important: Volume measurements may vary between methods. Clinical correlation is essential.
Important Medical Considerations
Limitations of PSA Density
- • Cannot definitively exclude prostate cancer
- • Affected by measurement accuracy
- • Age and ethnicity considerations needed
- • Should be interpreted with other factors
When to Consult a Urologist
- • PSA density ≥ 0.15 ng/mL²
- • Abnormal digital rectal exam
- • Strong family history of prostate cancer
- • Persistent PSA elevation