Winters Formula Calculator

Assess respiratory compensation in metabolic acidosis using Winters' equation

Calculate Expected pCO₂ Compensation

Normal range: 23-30 mmol/L. Enter low value for metabolic acidosis assessment.

Enter to assess adequacy of respiratory compensation

Example Calculations

Appropriate Compensation

Patient: HCO₃⁻ = 15 mmol/L (metabolic acidosis)

Winters Formula: pCO₂ = (1.5 × 15) + 8 = 30.5 ± 2 mmHg

Expected Range: 28.5 - 32.5 mmHg

Actual pCO₂: 30 mmHg → Appropriate compensation

Under-compensation

Patient: HCO₃⁻ = 12 mmol/L (severe metabolic acidosis)

Winters Formula: pCO₂ = (1.5 × 12) + 8 = 26 ± 2 mmHg

Expected Range: 24 - 28 mmHg

Actual pCO₂: 35 mmHg → Under-compensation (possible mixed disorder)

Winters Formula

Formula

pCO₂ = (1.5 × HCO₃⁻) + 8 ± 2

Purpose

Predict expected respiratory compensation in metabolic acidosis

Units

HCO₃⁻ in mmol/L, pCO₂ in mmHg

Range

±2 mmHg accounts for physiological variation

Normal Values

Bicarbonate (HCO₃⁻)

23 - 30 mmol/L

Normal range

Arterial pCO₂

35 - 45 mmHg

4.7 - 6.0 kPa

Metabolic Acidosis

HCO₃⁻ < 23 mmol/L

Triggers respiratory compensation

pH Range

7.35 - 7.45

Normal arterial pH

Clinical Applications

Metabolic Acidosis

Assess respiratory compensation adequacy

Mixed Disorders

Identify coexisting respiratory disorders

ICU Monitoring

Track acid-base status in critical patients

Emergency Medicine

Rapid assessment of compensation

Metabolic Acidosis Causes

High Anion Gap

  • • Diabetic ketoacidosis
  • • Lactic acidosis
  • • Renal failure
  • • Toxin ingestion

Normal Anion Gap

  • • Diarrhea
  • • Renal tubular acidosis
  • • Carbonic anhydrase inhibitors
  • • Ureterosigmoidostomy

Understanding Winters Formula

What is Winters Formula?

Winters formula predicts the expected respiratory compensation (pCO₂) in patients with metabolic acidosis. It helps clinicians assess whether the respiratory system is appropriately compensating for the metabolic disorder.

Clinical Significance

  • Evaluates adequacy of respiratory compensation
  • Identifies mixed acid-base disorders
  • Guides clinical assessment and treatment
  • Monitors patient's overall physiologic response

Formula Components

pCO₂ = (1.5 × HCO₃⁻) + 8 ± 2

1.5: Compensation factor (respiratory response ratio)
HCO₃⁻: Serum bicarbonate concentration (mmol/L)
8: Baseline constant (mmHg)
±2: Physiological variation range (mmHg)

Interpretation

Within range: Appropriate compensation
Above range: Under-compensation or respiratory acidosis
Below range: Over-compensation or respiratory alkalosis