Lille Score Calculator
Assess 6-month survival and steroid response in alcoholic hepatitis patients
Calculate Lille Score
Patient Information
Day 0 (Admission) Values
Normal: 11-15 seconds
Normal: 0.6-1.3 mg/dL (53-115 μmol/L)
Normal: 3.5-5.0 g/dL (35-50 g/L)
Normal: 0.3-1.2 mg/dL (5-21 μmol/L)
Day 7 (After Steroid Treatment) Values
Measured after 7 days of steroid therapy
Lille Score Results
⚠️ Critical Medical Warning
The Lille Score is a critical clinical decision tool for alcoholic hepatitis management. This calculator should only be used by qualified healthcare professionals.
Not for self-diagnosis: Results require proper clinical interpretation and should guide treatment decisions including steroid continuation, liver transplant evaluation, and palliative care planning.
Calculation Details
Example Calculation
Patient with Severe Alcoholic Hepatitis
Age: 50 years
PT: 18 seconds
Creatinine: 1.1 mg/dL
Albumin: 2.5 g/dL (25 g/L)
Bilirubin Day 0: 15 mg/dL (256.5 μmol/L)
Bilirubin Day 7: 12 mg/dL (205.2 μmol/L)
Calculation
Renal insufficiency: 0 (creatinine ≤ 1.3 mg/dL)
Bilirubin change: -51.3 μmol/L (improvement)
R: 3.19 - (0.101×50) + (0.147×25) + (0.0165×(-51.3)) - 0 - (0.0065×256.5) - (0.0096×18) = -0.82
Lille Score: exp(0.82)/(1+exp(0.82)) = 0.31
Interpretation: Good response to steroids (score < 0.45)
Lille Score Interpretation
Score < 0.45
Good steroid response
6-month survival > 77%
Score >= 0.45
Poor steroid response
6-month survival < 25%
When to Use Lille Score
- •Patients with alcoholic hepatitis on steroid therapy
- •After 7 days of corticosteroid treatment
- •To guide continuation or cessation of steroids
- •Liver transplant evaluation decisions
Normal Laboratory Values
Understanding the Lille Score
What is the Lille Score?
The Lille Score is a prognostic tool used to evaluate the response to corticosteroid therapy in patients with severe alcoholic hepatitis. It helps clinicians decide whether to continue or discontinue steroid treatment after 7 days.
Clinical Applications
- •Assess steroid response in alcoholic hepatitis
- •Predict 6-month survival probability
- •Guide treatment decisions
- •Identify candidates for liver transplant
Lille Score Formula
R = 3.19 - (0.101 × Age) + (0.147 × Albumin) + (0.0165 × ΔBilirubin) - (0.206 × Renal insufficiency) - (0.0065 × Bilirubin day 0) - (0.0096 × PT)
Lille Score = e-R / (1 + e-R)
- Age: Patient's age in years
- PT: Prothrombin time in seconds
- Albumin: Serum albumin in g/L
- ΔBilirubin: Bilirubin day 7 - day 0 (μmol/L)
- Renal insufficiency: 1 if creatinine > 1.3 mg/dL, 0 otherwise
Alcoholic Hepatitis Overview
Alcoholic hepatitis is a serious inflammatory condition of the liver caused by excessive alcohol consumption. It can range from mild to life-threatening and requires immediate medical attention and treatment.
Risk Factors
- • Heavy, prolonged alcohol consumption
- • Female gender (higher susceptibility)
- • Poor nutritional status
- • Genetic predisposition
- • Hepatitis C co-infection
- • Obesity
Clinical Features
- • Jaundice (yellowing of skin/eyes)
- • Abdominal pain and tenderness
- • Fever and malaise
- • Nausea and vomiting
- • Ascites (fluid accumulation)
- • Hepatic encephalopathy
Treatment Implications
Good Response (Score < 0.45)
- • Continue corticosteroid therapy for 28 days
- • Monitor for improvement in liver function
- • Focus on nutritional support
- • Plan alcohol cessation programs
- • Regular follow-up assessments
Poor Response (Score ≥ 0.45)
- • Discontinue corticosteroids immediately
- • Consider liver transplant evaluation
- • Implement palliative care measures
- • Treat complications aggressively
- • Family counseling and support